GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9369898 | 1 | rs6915187 | chr6:49423547 | CENPQ | chr6:49431096-49460820:+ | -0.29 | -5.57 | 2.36E-7 | Homocysteine levels |
| THYM | cis | rs6911965 | 1 | rs6916802 | chr6:24465722 | GPLD1 | chr6:24428405-24489850:- | 0.45 | 4.67 | 9.97E-6 | Hematological and biochemical traits |
| THYM | cis | rs9369898 | 1 | rs6916888 | chr6:49383804 | CENPQ | chr6:49431096-49460820:+ | -0.3 | -5.65 | 1.67E-7 | Homocysteine levels |
| THYM | cis | rs9369898 | 1 | rs6918347 | chr6:49406348 | CENPQ | chr6:49431096-49460820:+ | -0.29 | -5.57 | 2.36E-7 | Homocysteine levels |
| THYM | cis | rs9473555 | 1 | rs6923124 | chr6:49419864 | CENPQ | chr6:49431096-49460820:+ | -0.25 | -4.46 | 2.21E-5 | Folate pathway vitamin levels |
| THYM | cis | rs1577917 | 1 | rs6923148 | chr6:86767786 | SNHG5 | chr6:86386726-86388451:- | 0.58 | 7.92 | 4.5E-12 | Response to antipsychotic treatment |
| THYM | cis | rs6927188 | 1 | rs6927188 | chr6:42912589 | GNMT | chr6:42928500-42931617:+ | 0.36 | 5.36 | 5.88E-7 | Diabetic kidney disease |
| THYM | cis | rs6927188 | 1 | rs6927188 | chr6:42912589 | PEX6 | chr6:42931613-42946981:- | -0.51 | -4.78 | 6.43E-6 | Diabetic kidney disease |
| THYM | cis | rs6911965 | 1 | rs6928435 | chr6:24467366 | GPLD1 | chr6:24428405-24489850:- | 0.45 | 4.67 | 9.97E-6 | Hematological and biochemical traits |
| THYM | cis | rs9362426 | 1 | rs6930076 | chr6:88088654 | C6orf164 | chr6:88032306-88109459:+ | -0.5 | -4.96 | 3.14E-6 | Depressive episodes in bipolar disorder |
| THYM | cis | rs1577917 | 1 | rs6933377 | chr6:86705255 | SNHG5 | chr6:86386726-86388451:- | 0.43 | 4.91 | 3.72E-6 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs6936048 | chr6:86702608 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs568617 | 1 | rs693824 | chr11:65654783 | CTSW | chr11:65647284-65651212:+ | -0.59 | -7.12 | 2.04E-10 | Crohn's disease |
| THYM | cis | rs568617 | 1 | rs693824 | chr11:65654783 | SNX32 | chr11:65601410-65621170:+ | 0.55 | 5.17 | 1.29E-6 | Crohn's disease |
| THYM | cis | rs1577917 | 1 | rs6940458 | chr6:86644992 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |